Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke
TARDIS (ISRCTN47823388)
The 'Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke' (TARDIS) trial is a collaborative, international, multicentre, prospective, randomised, blinded endpoint, parallel-group, controlled trial designed to test the safety and efficacy of adding clopidogrel to aspirin and dipyridamole in patients with acute ischaemic stroke or TIA
5000 patients with acute ischaemic stroke or complex TIA will be enrolled within 48 hours of onset and treatment will be given for 30 days. The primary outcome is death or dependency (modified Rankin Scale) and will be determined at 90 days by observers blinded to treatment. Initially, a start-up phase, funded by BHF, in 350 patients in the UK will test safety, feasibility and tolerability.
If you are interested in having your centre join the trial, please fill in an Expression of Interest form and send/fax to the Coordinating Centre as per details at bottom of form.
TARDIS trial website and database
Enter LIVE TARDIS trial web-site
Status
As of 31 January 2010:
Enrolled patients: 38 - ischaemic stroke 25 (66%), TIA 13 (34%)
Active centres: 11
Over 50 centres have agreed to join the start-up phase of the trial.
Approvals: MHRA, MREC, ISRCTN, UK SRN adoption, local R+D
Funding
Forthcoming events
TARDIS will be present at:
News
- November 2009: Scottish SRN Investigator meeting, Glasgow, UK
- September 2009: Three centres now enrolling
- April 2009: First patient enrolled into trial, at Nottingham, UK
- March 2009: UK Investigator meeting, Nottingham, UK
- August 2008: Start-up phase of TARDIS trial funded by BHF
Documents
Newsletter 1 - December 2009 (PDF file)
Presentations/publications/listings/media
- December 2009: UK Stroke Forum, Glasgow, UK
- November 2009: Scottish Stroke Research Network Investigator Meeting, Glasgow, UK
- July 2009: UK Stroke Research Network Annual Conference, Newcastle, UK
- May 2009: Peninsula Stroke Research Network Annual Conference, Exeter, UK
- March 2009: UK Investigator meeting, Nottingham, UK
- February 2009: International Stroke Conference, San Diego, US
- December 2008: UK Stroke Forum, Harrogate, UK
Demo/practice website and database
Enter DEMO TARDIS demonstration/practice trial web-site
Study personnel
Trial Steering Committee:
Helen Rodgers (Newcastle, Independent Chair), Independent experts - to be appointed, Philip Bath (Nottingham, Chief Investigator), Stan Heptinstall (Nottingham), Hugh Markus (London), Ossie Newell (Nottingham, Patient representative), Tom Robinson (Leicester), Graham Venables (Sheffield), Representative of University of Nottingham/sponsor - to be appointed
Trial Management Committee (Nottingham):
Philip Bath (Chair), Margaret Adrian (Nurse Coordinator), Tim England (Medic), Chamila Geeganage (Medic), Michael Tracy (Statistician), Wim Clarke (Financial), Sue Williams (Secretary)
Independent Data Monitoring Committee:
Ian Ford (Glasgow, Chair), Cathie Sudlow (Edinburgh), Matthew Walters (Glasgow)
Independent Events Adjudicator:
Niki Sprigg (Nottingham)
Neuroimaging Adjudicators:
Jenny Becker
Transcranial doppler substudy:
PI: Hugh Markus (London)
Platelet substudy:
PI: Stan Heptinstall (Nottingham)
Programming/database management:
Graham Watson, Liz Walker (UK)
Contact details
TARDIS Trial Office
Division of Stroke Medicine
Institute of Neuroscience
University of Nottingham
Clinical Sciences Building
City Hospital campus
Hucknall Road
Nottingham NG5 1PB
UK
Telephone: +44 115 823 0210
Fax: +44 115 823 0273
E-mail: tardis@nottingham.ac.uk
Written by Philip Bath, last updated 3 February 2010
